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Chapter 17
biology • intermediate 12th

Chapter 17: Coordination and Control

Complete notes for Chapter 17 Coordination and Control. Covers plant hormones, nervous system, brain structure, endocrine glands, and animal behaviour for FSc Part 2 Biology.

Need for Coordination

All organisms show response to stimuli. It is a common characteristic of all organisms. These stimuli may be internal or external, at sub-molecular level, cellular level or organism level. There should be coordination between the activities of different parts of the body.

Need for Coordination

  1. Coordination integrates the different functions of body. These functions are essential for the organism's behaviour.
  2. Coordination is essential for the survival of an organism.
  3. In unicellular animals, coordination is present between various cellular processes. They show response to changes in their environment like temperature, light intensity, concentration of various chemicals and electric current.
  4. There is division of labour in multicellular animals, but response to change in environment needs coordination.

Limitation of Coordination

Organisms do not show response to every stimulus. Even the most developed animals like man are unable to detect and show response to many stimuli in our environment. For example, a large number of bacteria are present on our skin but we cannot show response because sensory cells of our body cannot detect them. On the other hand, some of our internal body cells show response by killing these bacteria by chemicals (antibodies) or by phagocytosis. We can see only visible radiation of spectrum of light, but our body cannot detect the non-visible radiation.

How Plants Coordinate

Plants can show response to their surroundings in many ways. In fact, a plant like any other organism, responds continuously to a variety of cues and signals both from within itself and from its environment. The responses are usually gradual and based on time-consuming chemical changes. They respond to their stimuli by:

  1. Controlling their body functions through plant hormones
  2. Regulating their growth and development in appropriate way

Plant Hormones

Hormones are chemical messengers that are manufactured in one part of an organism and are transported to another part where they can cause some sort of change. In some cases the messengers are not transported very far and may even act in same general area where they are manufactured. Hormones are effective in minute amounts and they are short-lived.

Functions of Hormones

Plant hormones are important in a number of ways. They are involved in growth, cell division, seed germination, flowering, tissue differentiation, dormancy and other vital activities. Hormonal control is however slow process.

After hormone is transported there is delay between its release, its arrival at target cells, and its action in body so response to stimulus that induce secretion of hormones is not immediate.

Types of Plant Hormones

  1. Auxins
  2. Gibberellins
  3. Cytokinins
  4. Abscisic Acid
  5. Ethene

Auxins

Auxins are a class of hormones that largely function in growth regulation in plants. They are very small molecules with far reaching effects. The principal naturally occurring auxin is indole acetic acid (IAA).

Functions of Auxins

  1. Promote cell enlargement in stems particularly by elongation of cells behind apical meristem. This is done by promoting cell division on cambium.
  2. Auxin allow the loosening of closely bound filaments of cellulose near the ends of young cell walls, thus permitting turgor pressure to expand cells in those areas.
  3. In roots it promotes growth at very low concentrations and inhibit growth at higher concentrations e.g. geotropism. Promotes growth of roots from cuttings.
  4. Working alone or in concert with other hormones, auxin also influences cell differentiation, growth in vascular cambium, fruit and leaf fall and even shape of plants.
  5. Promote bud initiation in shoots but sometimes are antagonistic to cytokinin.
  6. Auxins have the ability to both encourage and inhibit growth, working through principle of dominance.
  7. Sometimes induce parthenocarpy and may inhibit abscission.

Commercial Applications

The synthetic auxins are economic than IAA to produce and often more active in plants.

Synthetic AuxinApplication
NAA (Naphthalene acetic acid) / Indole propionic acidStimulates fruiting, helps mature fruit. Sometimes causes fruit setting in absence of pollination (parthenocarpy)
2,4-D (2,4-Dichloro phenoxy acetic acid)Selective weed killer. Kills broad leaved species (dicots). Used in cereal crops and lawns to eliminate weeds
IPCInhibits sprouting of potatoes
NAAPrevents premature fruit drop (retard abscission)

Gibberellins

The gibberellins are class of plant hormones that promote stem elongation and function in plant reproduction. They received their name from fungus in which they were first found, Gibberella fujikuroi.

Functions of Gibberellins

  1. Gibberellins can promote cell enlargement in presence of auxins. Dwarf corn for instance can be induced to grow to normal height after application of gibberellins.
  2. Promote cell division in apical meristem and cambium.
  3. They can stimulate pollen germination and pollen tube growth.
  4. May promote leaf growth, fruit growth, bud initiation in shoots, and bolting of some rosette plants.
  5. Gibberellins can enhance the action of auxins in apical dominance.
  6. Can break bud and seed dormancy.
  7. Gibberellins can promote flowering in long day plants as it may become substitute for red light.
  8. Other functions include inducing parthenocarpy and causing delay in leaf senescence.

Commercial Applications

  1. GAs promote fruit setting e.g. in tangerines and pears. Used for growing seedless grapes (parthenocarpy) and also increase the berry size.
  2. GAs is used in brewing industry to stimulate alpha amylase production in barley and this promotes malting.
  3. Gibberellins delay ripening and improve storage life of bananas and grapes.

Cytokinins

Cytokinins are a class of plant hormones that stimulate cell division and retard leaf aging. Plant researchers first learned about cytokinin by using coconut milk in cell cultures. They knew that some hormone in coconut milk was encouraging cell division in their cultures. For the first time cytokinin was isolated in 1964 and named zeatin.

Functions of Cytokinins

  1. They promote the growth of stem by cell division in apical meristem and cambium.
  2. They can inhibit primary root growth. On the other hand can promote lateral root growth.
  3. They can promote bud initiation, leaf growth, fruit growth, lateral bud growth and stomata opening.
  4. They can also induce parthenocarpy, break bud dormancy and delay leaf senescence.

Commercial Applications

  1. Synthetic cytokinins have been applied to harvested vegetables to extend their storage life.
  2. They delay aging of fresh leaf crops, such as cabbage and lettuce as well as keeping flowers fresh.
  3. They can also be used to break dormancy of some seeds.

Abscisic Acid

In the late 1940's plant researchers, encouraged by discovery of growth promoting hormones, found new growth inhibiting substances. In mid 1960s, one of the inhibitors was chemically identified and named abscisic acid (ABA). A chief source of ABA today is cotton plant.

Functions of Abscisic Acid

  1. ABA is involved in wilting by closing the stomata after excessive water loss.
  2. It inhibits stem and root growth notably during physiological stress e.g. drought and water logging.
  3. ABA is known to inhibit production of starch digesting enzyme alpha amylase in barley seeds, thus inhibiting germination.
  4. Can promote bud and seed dormancy, abscission, sometimes leaf senescence.
  5. ABA promotes flowering in short day plants and inhibits in long day plants.

Plant Movements and Environmental Responses

Plant responses to different environmental stimuli are largely restricted to specific growth patterns. Such growth responses in plants are called plant movements. Movements of plant organs are modified according to nature and intensity of external stimuli.

Types of Plant Movements

  1. Turgor Movements: These are due to changes in turgor pressure of cells.
  2. Growth Movements: These are due to differential growth on two sides of plant organs.

The stimuli of such growth movements are light, gravity, touch etc.

Types of Tropisms

TypeStimulusExamples
PhototropismLightShoots and coleoptiles are positively phototropic. Roots are negatively phototropic.
Gravitropism (Geotropism)GravityShoots and coleoptiles are negatively gravitropic. Roots are positively gravitropic.
ChemotropismChemicalsPollen tubes are positively chemotropic to chemicals produced at micropyle of ovule.
HydrotropismWaterRoots and pollen tubes are positively hydrotropic. Shoots are negatively hydrotropic.
ThigmotropismSolid surface or touchTendrils are positively thigmotropic. Tentacles of sundew are positively thigmotropic.

Environmental Stresses

  • Etiolation: If plants are grown without light, they become extremely long and fail to form chlorophyll. They are said to be etiolated.
  • Chlorosis: Many plants take on yellowish hue when they fail to form sufficient chlorophyll. This condition is known as chlorosis and usually arises from short supplies of mineral nutrients in the soil.
  • Defense against Pathogens: Many microorganisms such as virus, bacteria and fungi can attack the plants and cause several diseases. Plants respond when these microorganisms attack them. If they get wounded, they form a callus. Galls are growth on plant that are induced by parasites and usually highly organized. Gall tumors are induced by bacteria.

Biological Clock and Circadian Rhythms

In living things, behaviour or activities occur at regular intervals which are called biorhythms or biological rhythms.

Circadian Rhythms

Biorhythms may occur showing periodicity of about 24 hours. These are called circadian (Latin circa = about, dien = day) which means about one day, so they are also called diurnal rhythms. If biorhythms are about 365 days, these rhythmic activities are called circannual.

The organisms come across environmental changes that are cyclical in nature, such as days, tides and seasons etc. Many organisms maintain internal rhythm or clock to predict the onset of periodic changes and to keep them prepared for these changes.

Types of Stimuli for Biorhythms

  1. Exogenous Stimulus: External stimuli in which response is direct in various changes.
  2. Endogenous Stimulus: Internal stimuli that progress the organism's behaviour.
  3. Synchronization: Mechanism in which organism may receive exogenous or endogenous stimuli.

Factors Involved in Biological Rhythm

What makes biological clock is not clear. However rhythms exist in single cells so it is thought that clock must be intra-cellular. Cellular processes that may play role in timing processes are in one's genes. However environmental factors also affect to some extent. Thus biological clock is combination of rhythmical internal processes and timed events of environment.

Biological Clock in Drosophila

Erwin Bunning of the University of Tubingen, Germany has shown that exposure of fruit fly Drosophila to constant conditions for 15 consecutive generations failed to eliminate the essentially 25 hr rhythm of this insect.

Nervous Coordination

In animals coordination takes place by nervous coordination and chemical coordination.

Definition

The type of coordination which involves specialized cells called neurons is called nervous coordination. This type of coordination takes place with the help of neurons which are the functional and structural unit of nervous system.

Elements of Nervous System

  1. Receptors
  2. Neurons
  3. Effectors

Receptors

Receptors detect changes in the internal and external environment of animal. The receptor may be cell, or neuron, organ or receptor organ.

Classification of Receptors

  1. Chemoreceptors: These receptors detect chemicals. They are responsible for detecting chemicals not only in external environment, but the internal environment as well. These are for smell, taste and for blood carbon dioxide, oxygen, glucose, amino acids and fatty acids.
  2. Mechanoreceptors: They detect stimuli of touch, pressure, hearing and equilibrium.
  3. Photo Receptors: These receptors respond to stimuli of light, for example in eyes, rods and cones.
  4. Thermo Receptors: They are sensitive to temperature and show response to cold and warmth.
  5. Nociceptors: These are in different specialized nerve endings which produce the sensation of pain.
  6. Other Receptors: There are many receptors which respond to the mechanical conditions of the internal organs. Examples are the receptors of the stomach wall which may be concerned with arousal of hunger. Stretch receptors in carotid and aortic arteries of tetrapods have important roles in the regulation of blood pressure.

Modalities of Sensation

Each principal type of sensation that we can experience (pain, touch, sight, sound) is called modalities of sensation. Although we experience these different modalities of sensation, nerve fibres transmit only similar impulses. Each nerve tract terminates at specific point in CNS and type of sensation is determined by point in nervous system to which fibre leads.

Sensory Receptors in Skin

In skin, receptors are concerned with at least five different senses: touch, pressure, heat, cold and pain. Several types of tactile (touch) receptors are present in human skin. Touch receptors include Merkel's disks, Meissner's corpuscles and free nerve endings.

Meissner's Corpuscles

These lie in the papillae that extend into ridges of fingertips. The corpuscle consists of spirally and much twisted endings, each of which ends in a knob.

Pacinian Corpuscles

Pressure in skin is detected by bulbous Pacinian corpuscles which are located deeper in the skin and in some deep organs of body such as pancreas. Those located in the limbs probably form a basis for vibration sense.

Distribution of Receptors

Pain receptors are nearly 27 times more abundant than cold receptors. The cold receptors are not distributed evenly over entire surface of body. Touch receptors are much more numerous in finger tips than in skin of back, as might be expected in view of normal function of those two parts of body.

Transmission of Impulses

The stimulus received by receptor in skin which are the endings of sensory neurons is passed to motor neurons via inter or associative neurons which are present in brain and via spinal cord. Impulse is sent by motor neurons to effectors, which are muscles and glands.

Neurons

Neurons are chief structural and functional unit of nervous system. They are highly specialized cells capable of conducting electro-chemical nerve impulses.

Protection of Neurons

Neurons are protected, supported and insulated by surrounding neuroglia (or glia cells). Neuroglia cells make up as much as half of nervous system. Neuroglia are smaller than neurons and five to ten times as abundant. There are several types of neuroglia.

Structure of Neurons

Neuron consists of cell body which contains nucleus and most of cell's cytoplasm. The cytoplasm includes various organelles such as ribosomes, an endoplasmic reticulum, Nissl's granules, microtubules, mitochondria etc. Two major types of processes extend from cell body: the dendrites and the axons.

  • Dendrite: Receives signals and generally transmits them towards the cell body.
  • Axon: A nerve fiber that transmits neural impulse away from cell body. The axons may be meter long in some neurons.

The axons of many neurons outside the brain and spinal cord are covered by flattened and rolled Schwann cells, that contain fatty material called myelin forming myelin sheath. Nodes of Ranvier are spaces along a myelin of neuron that are gaps between individual Schwann cells.

Types of Neurons

There are three functional types of neurons:

  1. Sensory neurons: Carry impulses from receptors to CNS
  2. Associative (Inter) neurons: Present in brain and spinal cord, link sensory and motor neurons
  3. Motor neurons: Carry impulses from CNS to effectors

Effectors

The structures which respond when they are stimulated by impulse coming via motor neuron. The principal effectors are glands which respond by secreting and muscles which respond by contracting.

Reflex Arc

Reflex arc is the pathway of passage of impulse during a reflex action. Reflex action is type of involuntary action.

Components

Reflex involves receptors, neurons and effectors. The direction of stimulus is from receptor to sensory neurons, then from sensory neurons to associative neurons and finally from associative neuron to effectors.

Reflex Pathway

Receptor → Sensory neuron → Association neuron → Motor neuron → Effector

Types of Reflex

  1. Monosynaptic: Involves only single neuron network
  2. Polysynaptic: Involves more than one neuron

Transmission of Impulses

In the reflex arc, messages are generated in special receptors called stretch receptors that respond when it is elongated. The message is then transmitted to sensory neuron, which enters the spinal column through dorsal root of spinal nerve. The sensory neuron then excites the proper motor neuron. The motor neuron leaves the spinal cord through ventral root of spinal nerve and travels outward to effector (muscle group). In most of the reflex arcs, impulse is transmitted from sensory to motor neurons by an inter neuron.

Example: Pain withdrawal reflex - when a body part touches a damaging stimulus, the sensory neuron carries action potentials to muscles, causing them to contract and withdraw the body part from the damaging stimulus.

Membrane Potential

Nerve Impulse

Nerve impulse is a wave of electrochemical changes, which travels along the length of neuron involving chemical reaction and movement of ions across the cell membrane.

Membrane Potential

The electrical potential that exists across a cell membrane is known as membrane potential. In case of neuron, the charges are positive and negative ions and charge separating barrier is plasma membrane.

Resting Potential

The resting potential in a neuron refers to the period when no impulses are being transmitted. Resting neuron is polarized, that is the condition in which electrical charges outside the axon's plasma membrane are different from those inside. Specifically resting neuron is more negative inside than outside. Typically this potential difference is about -70 mV.

Factors Involved in Resting Membrane Potential

  1. Sodium and Potassium Ions: Sodium ions are tenfold higher in concentration outside than inside the membrane surface whereas potassium ions are twenty times more concentrated inside than outside. This distribution depends upon sodium-potassium pumps using ATP to power the mechanism. These pumps transport Na+ out and K+ into the cell, both against their respective concentration gradients. For every two K+ that are actively transported inward, three Na+ are pumped out.
  2. Negative Organic Ions: Some negative organic ions, which are large in size such as proteins cannot cross the membrane so they remain inside the axon, where they are only in negligible concentration. This makes the inside of neuron more negative.
  3. Leakage of Potassium Ions: The cell membrane is impermeable to all ions except K+. As the membrane is slightly permeable for K+, some of it leaks out of cell. The loss of this positive ion from neuron by diffusion accounts for more negative charge inside than outside the cell membrane of neuron.

Action Potential

Action potential in a neuron is a travelling depolarizing wave, a short-lived change in membrane potential that produces nerve impulses.

When a neuron is stimulated the point of stimulus becomes suddenly and briefly depolarized (without positively and negatively charged areas) and depolarization moves rapidly along the length of neuron followed within about 1 millisecond by repolarization. The depolarization is created by rapid change in membrane permeability and corresponding shift in ions. This shift of ions and electrical charges produces action potential.

Factors Involved in Action Potential

  1. Sodium and Potassium Ion Movements: When a neuron is stimulated the interior of neuron becomes slightly less negative. If this change is great enough then the permeability of membrane for sodium ions increases, moving them inwards, upsetting the potential making inside more positive than outside. Neuron physiologists believe that increased permeability is due to opening of specific pores in membrane termed "sodium gates". When these gates open, sodium ions rush into neuron by diffusion. Some K+ moves out.
  2. Charges are Reversed: The inner side of cell membrane has excess of positive ions at its internal surface and outer surface becomes more negative.
  3. Active Membrane Potential: Is about +30mV. These changes occur along the length of neuron till impulse reaches the synapse.

Soon after the passage of the impulse there is movement of small number of K+ ions inward. It restores the resting membrane potential. This neuron is ready to conduct another impulse.

Saltatory Impulses

In myelinated neuron, the impulse jumps from node to node (Nodes of Ranvier). This is called "saltatory impulses".

Speed of Nerve Impulse

The normal speed of nerve impulse in man is 100 meters per second. The maximum speed recorded is 120 meters per second.

Synapse

A synapse is a junction between one neuron and next, across which impulse passes, or between neuron and muscle cells.

Types of Synapse

1. Electrical Synapse

In cells communicating by electrical synapses the impulse travels directly from one cell to another cell. It permits very rapid transmission of an impulse with no interruption but they are very rare.

2. Chemical Synapse

In chemical synapse an electrochemical nerve impulse is converted into chemical signal that forms a bridge across the synapse between neurons. This bridge allows the chemical signal to pass to adjacent cells.

Neurotransmitters

The action potential cannot jump from one neuron to next directly. Rather the message is transmitted across synapse in form of chemical messenger called neurotransmitters. Neurotransmitters are chemicals which are released at axon ending of neurons at synapse.

Types of Neurotransmitters:

  1. Acetylcholine (main transmitter for synapses outside CNS)
  2. Adrenaline
  3. Norepinephrine
  4. Serotonin
  5. Dopamine

Transmission Across Chemical Synapse

This transmission is always one way. When synaptic neuron (one carrying the impulse) reaches the synapse, it initiates a series of events in synaptic bulbs, which are located at ends of axon terminals. Within the synaptic bulbs are thousands of synaptic vesicles filled with neurotransmitters.

Role of Neurotransmitter

  1. As the impulse reaches the synapse, vesicles are stimulated to fuse with presynaptic membrane
  2. They release their neurotransmitter molecules in synaptic cleft (narrow space between two cells)
  3. The neurotransmitter diffuses across the cleft and binds to specific receptors on membrane of post-synaptic cell
  4. When neurotransmitters are bound to receptors, chemical changes occur in post-synaptic plasma membrane that trigger impulse

Nervous System of Hydra and Planaria

Nervous System of Hydra

Hydra has diffused nervous system. The nervous system has network of neurons, which is present between ectoderm and endoderm. There is no head in this animal so there is no centralized nervous system i.e. no brain and nerve cords etc. However a cluster of neuron cell bodies forming ganglia can be seen here and there.

These neurons are so arranged in network that it is not possible to distinguish them in connected functional types of neurons as in higher animals i.e. no sensory, associative (inter/relay) neurons or motor neurons. There are no specialized sense organs or brain in this animal.

It has been observed that when any appropriate stimulus is given, Hydra responds and whole body responds as a unit. The tentacles are more responsive and react to stimulus instantaneously.

Nervous System of Planaria

Planaria has centralized nervous system.

  1. In the anterior region of the body of planaria there is a bilobed mass composed of two ganglia. This acts as a brain or centralized collection of nerves. This receives and sends messages from and to different parts of body. There is no such concentration of neurons or a coordinating center in Hydra, only a network of neurons is present.
  2. There is differentiation of neurons into sensory, associative and motor neurons. In Hydra all neurons are present in the "brain" and longitudinal nerves. Sensory neurons carry messages to brain or nerves and motor neurons carry messages from central nervous system to different parts of body.
  3. At the anterior region sense organs in the form of eyes and chemoreceptors are present. There are no specialized sensory organs in Hydra.
  4. The receptors for pressure, touch and chemical stimuli sensitive to light are present. There are no specialized sensory cells in Hydra but some nerve cells are more sensitive to particular stimulus chemical or mechanical than others.
  5. There are definite nerves, the longitudinal and lateral in planaria. There are no nerves in Hydra.
  6. In addition to superficial nerve net just below epidermis, there is deeper plexus embedded in parenchyma. In Hydra only superficial nerve net is present.

Central Nervous System of Man

Protection of Central Nervous System

Brain and spinal cord both are soft portions of the body so they are well protected. Cranium which is part of skull protects the brain and neural arches. The spinal cord is protected by vertebrae of vertebral column. The brain and spinal cord are directly enclosed by tough elastic coverings called meninges. The spaces between these membranes and cavities within brain itself are filled with pressurized shock-absorbing cerebrospinal fluid.

The central nervous system of man is divided into two portions: brain and spinal cord.

Brain

Human brain consists of three regions:

  1. Forebrain
  2. Midbrain
  3. Hindbrain

1. Forebrain

It is the largest and most dominant part of human brain. It is further divided into:

(i) Thalamus

The thalamus is located at the base of forebrain. It consists of densely packed neurons which provide connection between forebrain and hindbrain.

(ii) Limbic System

The limbic system is located in an area between thalamus and cerebrum. Limbic system works together to produce our more basic and primitive emotions, drives and behaviour such as hunger, rage, pleasure etc. Memory is formed in some of the portion of limbic system.

The limbic system consists of:

  • Hypothalamus: Major function is coordination of nervous system with endocrine system. Other than this, it controls body temperature, menstrual cycle, etc.
  • Amygdala: Clusters of neurons which produce sensations of pleasure when stimulated. It is also involved in feelings of fear and rage.
  • Hippocampus: An important figure in memory of recent events. Without the hippocampus, people may be unable to complete a sentence because they forgot how it began.
  • Nearby region of cerebrum
(iii) Cerebrum

Cerebrum is the largest part of brain and is divided into two halves called cerebral hemispheres. These halves communicate with each other by means of a band of axons called corpus callosum. Tens of billions of neurons are packed in this part.

The outer region, the cerebral cortex, forms folds called convolutions which greatly increase its surface area. This part receives sensory information, processes it, stores some in memory for future use, directs voluntary movements and is responsible for poorly understood process that we call thinking. The left cerebral hemisphere controls right side of body and right controls left side.

Cerebral Cortex: The outer layer of cerebrum is called cerebral cortex which is of gray unmyelinated cells. It receives signals from sensory organs such as eyes and ears. This area is also involved in speech and also interprets sensations of touch from all parts of body. It is also a center for sending impulses to voluntary muscles controlling movements. This is also involved in intelligence, reasoning and judgement.

2. Midbrain

Midbrain connects the hindbrain and forebrain. It is very reduced in humans and processes information from ears and eyes. Midbrain contains reticular formation which is very important in screening the input information before they reach higher brain centers.

3. Hindbrain

Hindbrain consists of medulla, pons and cerebellum.

(i) Medulla

The medulla oblongata is directly connected to spinal cord and has centers of nuclei that help regulate such functions as breathing rate, blood pressure and heart rate. All communication between brain and spinal column must pass through medulla.

(ii) Pons

Pons which is just above the medulla contains ascending and descending nerve tracts that run between brain and spinal cord. It appears to influence transitions between sleep and wakefulness and rate or pattern of breathing.

(iii) Cerebellum

Cerebellum is a large bulbous structure with general appearance of two halves of an enlarged walnut. It guides smooth and accurate motions and initiates body position. The cerebellum is also involved in learning and memory storage for behaviour. It is best developed in birds, which engage in complex activity of flight.

Spinal Cord

The spinal cord is a cylinder of nervous tissue that extends from medulla oblongata of brain. It is sheltered in vertebral column. It is made up of very large number of neurons, the cell fibers and bodies of which are arranged in a definite pattern.

In cross section the spinal cord shows two areas:

  • Grey Matter: An inner butterfly-shaped grey matter. It contains a central canal. Grey matter consists of cell bodies and non-myelinated nerve fibers and tracts.
  • White Matter: The outer portion is composed of white matter which is made up of myelinated nerve fibers or tracts.

Functions of Spinal Cord

  1. It serves as primary link between brain and outer parts of nervous system and thus acts as a dual receptor of impulses from and to different parts of body.
  2. The second main function of spinal cord is to serve as reflex center.

Peripheral Nervous System

Peripheral nervous system includes all the neural structures that lie outside the central nervous system. It comprises sensory neurons and motor neurons, which may form ganglia and nerves. Ganglia are the concentrations of cell bodies of neurons. The nerves are the bundles of axons or dendrites, bounded by connective tissues.

Division

Peripheral nervous system is further divided into two functionally different systems:

  1. Somatic System
  2. Autonomic Nervous System

Somatic System

It includes sensory pathway and motor pathways. The control of voluntary movements which are under conscious control of body involving skeletal muscles.

Autonomic Nervous System (ANS)

The autonomic nervous system is essentially a motor system. This means that it carries impulses from brain and spinal cord to organs it serves. The general function of autonomic nervous system is to promote homeostasis.

Division of Autonomic Nervous System

(i) Sympathetic System

This system is generally active during emergency or threatening conditions. It is often referred to as the "fight or flight" system. This system accelerates the heart beat and dilates bronchi and inhibits digestive tract.

(ii) Parasympathetic System

A few cranial nerves including the vagus nerve together with fibers from the bottom portion of spinal cord form the parasympathetic nervous system. This system is active when the body is calm and at rest and controls such responses as contraction of pupils, promoting digestion of food, and retards heartbeat.

Nervous Disorders

1. Parkinson's Disease

This is a nervous disorder in which involuntary tremors and diminishing of motor power and rigidity occurs. Onset of this disease is in 50's and 60's.

Cause: It causes cell death in brain area which produces dopamine. The disease is slowly progressive and patient may result by head trauma.

Drugs: Drugs available are (i) L-dopa (ii) naturally occurring protein called glial cell line derived neuro-trophic factor (GDNF).

2. Epilepsy

It is one of the convulsive disorders of nervous system which are characterized by abrupt transient symptoms of motor, sensory, psychic or autonomic nature frequently associated with changes in consciousness. These changes are believed to be secondary to sudden transient alterations in brain function associated with excessive rapid electric discharges in gray matter.

The onset of epilepsy is usually before age 30. Later age onset suggests organic disease. In some patients, emotional disturbances play a significant trigger role.

Treatment: Electroencephalography is most important test in study of epilepsy. Anticonvulsant drugs are used. Alcohol aggravates the situation.

3. Alzheimer's Disease

Alzheimer's disease was first described by Alois Alzheimer in 1907.

Symptoms: The brain functioning is highly affected. The memory is lost in this disease.

Causes: The causes of this disease are genetic so it runs in families. High levels of aluminium is also a reason.

Effects of Drugs on Coordination

Nicotine affects post-synaptic membrane in CNS and PNS. It minimizes the action of acetylcholine on nicotine receptors so it is stimulant of nerve impulse. The effects of this drug are increased heart beat, blood pressure and digestive tract mobility. Nicotine may induce vomiting and diarrhea and even may cause water retention by kidneys.

Endocrine Glands and Hormones

Chemical coordination takes place with the help of endocrine system which comprises endocrine glands in various parts of body which secrete hormones. The endocrine glands are ductless glands.

Hormones

Hormones are organic compounds of varying complexity. They are effective in minute quantities. They are poured directly into blood which cause changes only in target cells that respond to hormone.

Functions: They do not initiate new biochemical reactions but produce their effects by regulating enzymatic and other chemical reactions. Hormones may also control some long-term changes such as rate of growth, rate of metabolic activity and sexual maturity.

Chemical Composition:

  1. Some are proteins in nature such as insulin and glucagon
  2. Some are amino acids and derivatives, e.g. thyroxine, T3, epinephrine
  3. Others are polypeptides, vasopressin and oxytocin
  4. Steroids, oestrogens, cortisone are also found

Role of Hypothalamus

It is a part of forebrain. It is here that many of sensory stimuli of nervous system are converted into hormonal responses. It is believed that oxytocin and antidiuretic hormone (ADH) are produced in hypothalamus and travel down the nerves to the posterior lobe of pituitary to be stored. They are released from their storage after receiving nerve impulses from hypothalamus.

The Pituitary Gland

It is a tiny lobed structure about size of kidney bean. It is about 0.5 gm in the adult and is connected to brain through a short stalk called infundibulum.

Lobes

It has three lobes: anterior, median and posterior. The anterior lobe is referred to as "master gland" because in addition to producing primary hormones it produces the trophic hormones which control the secretion of hormones in many of other endocrine glands.

Anterior Lobe Hormones

1. Somatotrophin (STH)

Somatotrophin releasing factor (SRF) is secreted from hypothalamus throughout life. It is essential for normal growth. Although bones and muscles are their major targets, if it is too much secreted then it can produce pituitary giants (gigantism) which leads to abnormal development. People severely affected by this condition may grow to be 7 to 9 feet tall. If there is under secretion, dwarfism results.

2. Thyroid Stimulating Hormone (TSH)

Also known as thyrotrophin. The release of TSH from hypothalamus is controlled by levels of thyroxine in blood. In presence of low levels of thyroxine, there is increasing production of TSH. It acts on thyroid gland. It is secreted throughout life but particularly reaches high levels during periods of rapid growth and development. It acts directly on cells of the thyroid gland increasing both their numbers and their secretory activity.

3. Adrenocorticotrophic Hormone (ACTH)

First stimulated by hypothalamus and is then regulated by negative feedback control system. The target of ACTH is cortex of adrenal gland. Excess and deficiency results in disturbance of normal adrenal function.

4. Gonadotrophic Hormones

These are follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin.

FSH: In females it stimulates follicle development and secretion of estrogens from the ovaries. In males stimulates development of germinal epithelium of testis and sperm production.

LH: Works with FSH to stimulate estrogen secretion and rupture of mature follicles to release egg or ovum. It also causes the lutenisation of the follicle and acts synergistically with prolactin to maintain corpus luteum. In males it stimulates interstitial cells of testes to secrete testosterone.

Prolactin: Promotes milk production in mammals. Toward the end of pregnancy the blood level of prolactin increases dramatically as mother prepares to nurse her offspring.

Median Lobe

Melanophore Stimulating Hormone (MSH): Its secretion is controlled by hypothalamus. External light governs its secretion. During pregnancy its secretion increases. It stimulates melanocytes in skin to produce brown pigment melanin which darkens the skin. Excess MSH is secreted in Addison's disease in which skin becomes dark.

Posterior Lobe Hormones

Antidiuretic Hormone (ADH) or Vasopressin: Antidiuretic is an agent that decreases urine volume by bringing about an increase in the recovery of water by urine collecting ducts of kidney. It is secreted when there is decrease in blood pressure, blood volume and osmotic pressure of blood detected by osmoreceptors in hypothalamus. A lack of this hormone produces diabetes insipidus in which large quantities of urine is excreted and patient feels great thirst.

Oxytocin: Its release depends upon the decrease in progesterone level in blood and neural stimuli during parturition and suckling. Primary action is on smooth muscle, particularly uterus during childbirth and causes milk ejection from mammary gland.

Thyroid and Parathyroid Glands

Thyroid Gland

The thyroid gland is shaped somewhat like a bow tie and is located in front of the larynx. It secretes three hormones:

  1. Thyroxine (Tetraiodothyronine or T4)
  2. Triiodothyronine (T3)
  3. Calcitonin

Thyroxine (T4) and Triiodothyronine (T3)

T4 and T3 have same targets and action, but whereas T4 is more abundant, T3 is much more powerful.

Functions:

  1. Both of them increase rate at which carbohydrates are oxidized by cells throughout body and accordingly the amount of heat and ATP produced. The rate of oxidation is called basal metabolic rate.
  2. They also act in conjunction with somatotropin in bringing about growth and act directly on brain cells causing them to differentiate.
  3. In amphibians they affect the process of metamorphosis. If secretion of thyroid is deficient in tadpole larva, it will become large-sized tadpole.

Thyroid Abnormalities

  • Grave's Disease: If thyroxine is produced in excess then a condition called Grave's disease is produced. This disease is characterized by rapid metabolism, weight loss, nervousness and insomnia. In some instances the eyes may bulge out noticeably, a condition known as exophthalmia goiter.
  • Goiter: Deficiency later in life, perhaps due to iodine shortage in diet, produces a swelling of neck (goiter) and may lead to laying down of excess fat and weight increase.
  • Cretinism: If congenitally deficient, the lack of thyroxin causes cretinism, where individuals fail to develop normally. These are small, have coarse scanty hair, thick yellowish scaly skin and are mentally retarded. There is also failure to develop sexually.
  • Myxoedema: Decrease in thyroxine leads to condition known as myxoedema in which there is puffiness of hands and skin. Reduced metabolism, body temperature and pulse rate results.

Calcitonin

This is the third hormone and works in concert with hormone from parathyroid glands in regulating calcium ion level in blood. Calcitonin inhibits bone breakdown and accelerates the uptake of calcium ions by bone, thereby lowering blood level of calcium.

Parathyroid Glands

Parathyroid glands are pea-sized bodies embedded in the posterior part of lateral lobes of thyroid. These produce hormone called parathormone. This is a polypeptide that helps raise the calcium levels of the blood acting as an antagonist of calcitonin.

Effects of Parathormone: Increases calcium ion concentration in blood, decreases calcium excretion by kidneys, speeds calcium uptake by intestine and increases calcium release from bones into blood stream.

Abnormalities: Low levels of parathyroid hormone cause muscle convulsions and eventually death. In high level of parathyroid hormone, severe decalcification of bone (osteoporosis) occurs in which the fibrous cysts are formed in skeleton.

Islets of Langerhans and Adrenal Glands

Pancreas

The pancreas is a ducted exocrine gland since its major secretions (digestive enzymes and sodium bicarbonate) are released into small intestine.

Islets of Langerhans

Scattered through the pancreas are groups of true endocrine cells. These clumps of cells are islets of Langerhans. Each clump consists of alpha, beta and delta cells. This hormone is under the control of STH and ACTH secreted by pituitary.

Glucagon

Alpha cells produce glucagon and it is released in blood stream when glucose levels fall below a certain level and increases the glucose level. It does this mainly by promoting breakdown of glycogen to glucose in liver and muscles. It also increases the rate of breakdown of fats.

Abnormalities: Glucagon abnormalities seem rare as endocrine disorders. Tumors on cells which damage alpha cells will cause excess glucagon secretion and consequent high blood glucose levels.

Insulin

The beta cells secrete insulin.

Functions:

  1. Acts on plasma membranes and helps move glucose into cells, where it can be metabolized
  2. Stimulates muscle and liver cells to store glucose as glycogen
  3. Insulin stimulates conversion of glucose into lipid and protein which in turn reduces glucose level
  4. Insulin inhibits breakdown of glycogen in liver and muscles

Abnormalities: Failure to produce insulin leads to a condition called diabetes mellitus. The symptoms are high level of blood sugar, sugar in urine, a disturbance of body's osmotic equilibrium. Toxic metabolites from fat also accumulate and are only lost from kidney with valuable metal cations. The body becomes dehydrated. If excess insulin is produced, the utilization of sugar is too great and its level falls in the blood which upsets nerve and muscle functioning.

Adrenal Gland

"Ad" means on and "renal" means kidney, thus adrenal gland is present at the top of kidney. The outer layer of this gland is called cortex and inner is called medulla.

Adrenal Cortex

Adrenal cortex is active all the time but especially in shock or stress condition. It secretes aldosterone, cortisol and androgenic hormones.

  • Aldosterone: Promotes the retention of sodium ions and release of potassium ions by kidney. Also promotes inflammation as part of body immune defense reactions.
  • Cortisol: Brings about an increase in blood glucose level mainly by its production from protein and by antagonizing the action of insulin.
  • Androgens: Play an important role in sexual development. As they secrete estrogen and testosterone, they promote the secondary sex characters such as beards in men and sexual characters in women.

Abnormalities:

  • Addison's Disease: The destruction of adrenal cortex leads to general metabolic disturbance, in particular weakness of muscle action and loss of salts. Stress situations such as cold which would normally be overcome lead to collapse and death.
  • Cushing's Disease: Too much cortical hormone is produced. Its symptoms are an excessive protein breakdown resulting in muscular and bone weakness. The high blood sugar level disturbs the metabolism.
Adrenal Medulla

The adrenal medulla produces hormones adrenaline (epinephrine) and noradrenaline (norepinephrine). Both adrenaline and noradrenaline are secreted in stress situations. They can cause specific changes in the body.

Adrenaline dilates blood vessels in certain parts of body such as skeletal muscles and increases heart output. Noradrenaline constricts blood vessels so effect of two hormones are synergistic in raising blood pressure. Adrenaline and noradrenaline promote the release of glucose from liver glycogen, in a way reinforcing the effects of sympathetic system.

Gonads and Gut Hormones

Gonads

The male gonad is called testis and female gonad is called ovary.

Ovary

The ovary produces two hormones: estrogens and progesterone.

Estrogens

Oestrogens are secreted by ripening follicles whose development has been stimulated by FSH from pituitary.

Functions:

  1. Oestrogens bring about development of secondary sexual characters in female such as thickening of uterine wall and regulation of menstruation.
  2. They help in regrowth of uterine wall after menstruation.
  3. Under the influence of oestrogens some of cells of uterine walls become glandular and start secreting proteinaceous secretions which are taken up by embryo when in its early stages of development.

Abnormalities: Deficiency of sex hormones leads the young to failure to mature sexually and sterility in adults.

Progesterone

It is produced by ruptured follicle in response to LH from pituitary.

Functions:

  1. Progesterone inhibits further FSH secretion from pituitary, thus preventing any more follicles from ripening.
  2. It also affects the uterus, causing further thickening and vascularization of its wall.
  3. It also prepares the female for milk production.
  4. Suppresses ovulation.

Testis

The testis consists of many coiled seminiferous tubules where the spermatozoa develop and between the tubules region of interstitial cells the hormones testosterone and dehydroxy testosterone are produced.

Testosterone

Testosterone initiates the development of sex organs in foetus. At puberty it brings about development of male secondary characters. The castrated male fails to develop secondary sexual characteristics and his body tends more towards the form of immature females.

Gut Hormones

Some of the parts of gut function as endocrine tissue.

  • Gastrin: The mucosa of pyloric end of the stomach produces a hormone called gastrin. It promotes the secretion of gastric juice. Its production is influenced by intake of protein containing food.
  • Secretin: The duodenum produces secretin especially when the food contains acid. It affects pancreas to produce and release pancreatic juice and also affects the rate of bile production in liver.

Feedback Mechanism

Definition

It is a type of interaction in which controlling mechanism is itself controlled by the products of reactions it is controlling.

Explanation

Hormone secretion is regulated by feedback mechanism. For proper functioning two opposing systems are required:

  1. Accelerators: In this system hormone promotes or stimulates the reactions.
  2. Inhibitors: In this system another hormone will check the reaction.

In this way concentration of secretions is itself controlled because certain information is passed to the source, in other words, is "fed back" so that the output of secretion is adjusted accordingly depending on the body needs.

Example: Thyroid Gland Feedback

The interaction between pituitary and other endocrine gland is considered best example of feedback control. Feedback of thyroid gland function is as follows:

  1. In the case of low body temperature or stress, neurosecretory cells of hypothalamus secrete thyroid stimulating hormone-releasing hormone (TRH) to anterior pituitary.
  2. The pituitary then secretes Thyroid Stimulating Hormone (TSH).
  3. TSH causes the thyroid gland to secrete hormone thyroxine.
  4. Thyroxine causes an increase in metabolic activity of most body cells in generating ATP energy and heat.
  5. This results in more TSH production.

The levels of both hormones are thus kept within tight limits because of the influence they exert on each other. This is called negative feedback.

Comparison: Nervous and Chemical Coordination

Similarities

  1. Both hormone producing cells and nerve cells (neurons) synthesize chemical messengers.
  2. Both release the messenger chemicals in extracellular spaces of the body.
  3. Both help in coordination of the body.
  4. Both function in response to specific stimuli either from within the body or from the external environment.
  5. Both are homeostatic in function.

Differences

Nervous CoordinationChemical Coordination
Neurons (sensory, associative and motor) are the basic units of structure and function. Neuroglial cells provide nutrition and protection to neurons.Hormone producing cells and neurosecretory cells release hormones and are units of structure and function.
Chemicals produced by neuron endings act where they are produced, i.e. very close to the cells they influence, commonly less than a micrometer away.Hormones (or neurohormones) are poured into and transported by blood. These hormones affect the target cells, which are far away from where the hormones are produced.
Neurons release neurotransmitter onto one or a small group of specific cells.The blood-borne hormones bathe millions of cells indiscriminately and only a few respond to these hormones.
Show immediate effect or show response to a stimulus instantly.May have immediate effects (e.g. insulin), but mostly hormones have prolonged or delayed effects (e.g. growth hormones).
Control is affected through the electrical signals that travel within the cell itself.Control involves only chemical stimulation and the target cells are far away from them.
Shows faster or rapid effect. Speed of impulse in most cases is 100 m/s; maximum speed recorded in human beings is 120 m/s.It is not very rapid, but shows slow but prolonged effects.
The neurotransmitters are short-lived, broken down shortly after their release. Effects tend to be of much shorter duration.Hormones remain active for much longer duration within the blood and thus have much longer duration for their actions.

Animal Behaviour

Definition

Behaviour is defined as a change in response to stimulus. In other words, animal behaviour is the sum of everything that animals do, i.e. flying, walking, sitting, sleeping, eating, mating, rearing young ones, etc.

Types of Behaviour

Behaviour is divided into two main types:

  1. Innate Behaviour
  2. Learned Behaviour

1. Innate Behaviour

It is a collection of responses that are predetermined by the inheritance of specific nerve or cytoplasmic pathways in multicellular or unicellular organisms. As a result of the built-in pathways, a given stimulus would produce invariably the same response. All plant behaviour is innate.

Importance: These behaviour patterns have been developed and refined over many generations and their primary adaptive significance lies in their survival value to the species. Another importance is the economy it places on nerve pathways since it does not demand higher centers of nervous system.

Types of Innate Behaviour
  • Orientation: Further divided into kinesis and taxes
  • Reflexes and Instincts: Simple reactions to external stimulation

Kinesis: This is behaviour of organism which is performed without attention to its position in space. The organism changes the speed of random movements which help them in surviving in environment, e.g. this type of behaviour allows pill bugs to reach moist area which is necessary for their life.

Taxes: When an organism moves toward or away from a source of stimulation, the action is called taxis. The stimuli may be light, chemicals etc.

Reflexes: Among the simplest forms of behaviour are reflexes, simple reactions to external stimulation. A stimulus such as light intensity or touch can trigger an automatic, involuntary response. A classic example is human knee-jerk reflex. These include biological rhythms, territorial behaviour, courtship, mating, aggression etc.

2. Instinct Behaviour

Darwin was first who gave the definition of instinct behaviour. According to him it is complex reflexes made up of units compatible with mechanisms of inheritance and thus a product of natural selection, that had evolved together with other aspects of life.

Sign Stimulus: The early ethologists thought that animals sometimes respond instinctively to specific though often complex stimuli. Such stimulus is called sign stimulus. For example, male three-spined stickleback has red belly in breeding season. This is sign stimulus which makes it aggressive to other territorial males.

Learning Behaviour

Thorpe defined learning as "that process which manifests itself by adaptive changes in individual behaviour as a result of experiences".

Types of Learning Behaviour

1. Imprinting

It is another form of learning which can be seen in ducks, birds, geese etc. After hatching, these young birds soon have the tendency to follow those objects which are moving in front of them and show a brief sensitive period during which the shape or form of objects can be imprinted. Due to this behaviour the young birds will follow those imprinted objects. Usually the first moving object in front of the young is his mother and therefore will adapt and learn from her appearance and follow her. However, if the parent is absent, the young bird may imprint on other species of birds, human beings or any other moving object. In later life such birds will attempt to court and mate with imprinted objects instead of adults of their own species.

2. Habituation

Habituation is the simplest form of learning and involves modification of behaviour through a diminution of response to repeated stimuli. A loss of receptivity to repetitions stimuli can be useful in preventing a drain of energy and attention for trivial purposes.

Examples:

  • A snail crawling on a sheet of glass retracts into its shell if the glass is tapped. After a pause it emerges and continues moving. A second tap causes retraction again but it emerges more quickly. Ultimately tapping has no effect and snail ceases to respond.
  • Rodents respond to alarm calls by others in their group; if these calls are continued and no danger is confirmed, further calls may be ignored.
3. Conditioning (Conditioned Reflex Type I)

Involves the pairing of an irrelevant stimulus with a natural primary stimulus that elicits an automatic response.

Example: Pavlov conditioned the dogs to secrete saliva on ringing of the bell, which is not normal stimulus for secretion of saliva. In his experiments, he would ring the bell just before giving food to the dogs, so the dogs became conditioned to secondary stimulus or conditioned stimulus (ringing of bell) and started secreting saliva in response to it as if it were the natural stimulus.

4. Operant Conditioning (Conditioned Reflex Type II)

Also called trial and error learning. It is a more complex type of learning than habituation. This type of learning has been demonstrated and studied by Thorndike and B.F. Skinner. Under natural conditions, the achievement of a particular goal is the reward that directs random activities into a habitual action by a trial and error repetitions, step by step.

Example: Experiments on rats were performed to run a maze to either get or find food, or to depress a lever and come out of the cage. In this case first experiment is accidental and then it is rewarded, animal acts with latter experience.

5. Latent Learning

Thorpe defined latent learning as the association of indifferent stimuli or situations without patent reward.

Example: Suppose we put a rat in a maze as it wanders about and accidentally gets food. If we put the rat in the same maze again, it may directly reach the food. That means when the rat was wandering, it did learn something without even the incentive of any reward.

6. Insight Learning

Keller performed many experiments on chimpanzees and showed that they have higher form of learning called insight learning. Insight learning is an extreme case of behavioural modification involving the application of insight or reasoning to a novel situation. If an animal can direct its behaviour to solve a problem for which it has no previous experience then reasoning is involved. This is the highest form of learning.

Example: A chimpanzee is placed in a cage in which a choice piece of fruit hangs from the ceiling. The chimp cannot reach the fruit, but the keeper has placed some boxes of different sizes in the cage. After a short period of head scratching, the chimp moves the largest box and piles other smaller boxes over it, and climbs up to reach the fruit.

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